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Target
Ubiquitin carboxyl-terminal hydrolase 7
Ligand
BDBM50465200
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation (FP) Homogeneous Assay
IC50
<250±n/a nM
Citation
 O''Dowd, C; Harrison, T; Hewitt, P; Rountree, S; Hugues, M; Burkamp, F; Jordan, LD; Helm, M; Broccatelli, F; Crawford, JJ; Gazzard, L; Wertz, I; Lee, W Piperidine derivatives as inhibitors of ubiquitin specific protease 7 US Patent  US10766903 Publication Date 9/8/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 7
Synonyms:
Deubiquitinating enzyme 7 | HAUSP | Herpesvirus-associated ubiquitin-specific protease | UBP7_HUMAN | USP7 | Ubiquitin thioesterase 7 | Ubiquitin-specific-processing protease 7
Type:
PROTEIN
Mol. Mass.:
128274.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469483
Residue:
1102
Sequence:
MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN
  
Inhibitor
Name:
BDBM50465200
Synonyms:
CHEMBL4282783 | US10766903, Example 97
Type:
Small organic molecule
Emp. Form.:
C28H30FN5O3
Mol. Mass.:
503.5679
SMILES:
C[C@H](CC(=O)N1CCC(O)(Cn2cnc3c(-c4ccccc4F)n(C)nc3c2=O)CC1)c1ccccc1 |r,wD:1.0,(18.13,-20.03,;18.13,-18.49,;16.8,-17.72,;15.46,-18.49,;15.46,-20.03,;14.13,-17.72,;12.8,-18.48,;11.47,-17.72,;11.47,-16.18,;11.46,-14.64,;10.14,-15.41,;8.8,-16.19,;8.81,-17.73,;7.47,-18.5,;6.13,-17.73,;4.66,-18.21,;3.89,-19.54,;2.35,-19.53,;1.58,-20.86,;2.34,-22.2,;3.89,-22.2,;4.66,-20.87,;6.2,-20.87,;3.75,-16.96,;2.21,-16.96,;4.66,-15.7,;6.13,-16.18,;7.47,-15.42,;7.46,-13.88,;12.8,-15.4,;14.13,-16.18,;19.47,-17.73,;20.8,-18.5,;22.13,-17.73,;22.13,-16.19,;20.79,-15.42,;19.46,-16.19,)|
Structure:
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