Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 7
Ligand
BDBM462568
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation (FP) Homogeneous Assay
IC50
<250±n/a nM
Citation
 O''Dowd, C; Harrison, T; Hewitt, P; Rountree, S; Hugues, M; Burkamp, F; Jordan, LD; Helm, M; Broccatelli, F; Crawford, JJ; Gazzard, L; Wertz, I; Lee, W Piperidine derivatives as inhibitors of ubiquitin specific protease 7 US Patent  US10766903 Publication Date 9/8/2020 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 7
Synonyms:
Deubiquitinating enzyme 7 | HAUSP | Herpesvirus-associated ubiquitin-specific protease | UBP7_HUMAN | USP7 | Ubiquitin thioesterase 7 | Ubiquitin-specific-processing protease 7
Type:
PROTEIN
Mol. Mass.:
128274.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469483
Residue:
1102
Sequence:
MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN
  
Inhibitor
Name:
BDBM462568
Synonyms:
3-((4-hydroxy-1- ((R)-3- phenylbutanoyl) piperidin-4- yl)methyl)-6- ((1R,5S)-3-methyl- 3,6- diazabicyclo[3.2.1] octan-6- yl)pyrimidin-4(3H)- one [first eluted by analytical SFC: | US10766903, Example 180
Type:
Small organic molecule
Emp. Form.:
C27H37N5O3
Mol. Mass.:
479.6144
SMILES:
C[C@H](CC(=O)N1CCC(O)(Cn2cnc(cc2=O)N2C[C@@H]3C[C@H]2CN(C)C3)CC1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: