Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM280476
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling Assay
IC50
550±n/a nM
Citation
 Buzard, DJ; Shaghafi, MB; Cisar, JS; Grice, CA; Jones, TK; Weber, OD Spirocycle compounds and methods of making and using same US Patent  US10781211 Publication Date 9/22/2020 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
38216.17
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells.
Residue:
336
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
  
Inhibitor
Name:
BDBM280476
Synonyms:
US10030020, Example 21 | US10781211, Example 21
Type:
Small organic molecule
Emp. Form.:
C23H28ClF6N3O3
Mol. Mass.:
543.93
SMILES:
FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3ccc(Cl)cc3N3CCOCC3)C2)CC1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: