Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM280559
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling Assay
IC50
>1000±n/a nM
Citation
 Buzard, DJ; Shaghafi, MB; Cisar, JS; Grice, CA; Jones, TK; Weber, OD Spirocycle compounds and methods of making and using same US Patent  US10781211 Publication Date 9/22/2020 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
38216.17
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells.
Residue:
336
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
  
Inhibitor
Name:
BDBM280559
Synonyms:
US10030020, Example 104 | US10781211, Example 104
Type:
Small organic molecule
Emp. Form.:
C26H33ClF6N4O3
Mol. Mass.:
599.009
SMILES:
CC(=O)NC1CCN(CC1)c1cc(Cl)ccc1CN1CCCC11CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F
Structure:
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