Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM280584
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling Assay
IC50
>1000±n/a nM
Citation
Buzard, DJ; Shaghafi, MB; Cisar, JS; Grice, CA; Jones, TK; Weber, OD Spirocycle compounds and methods of making and using same US Patent US10781211 Publication Date 9/22/2020
More Info.:
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
38216.17
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells.
Residue:
336
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN