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Target
Amino acid transporter
Ligand
BDBM464401
Substrate
n/a
Meas. Tech.
3H-Amino Acid Uptake Assays
IC50
57200±n/a nM
Citation
 Manning, HC; Schulte, M Glutamine transport inhibitors and methods for treating cancer US Patent  US10793514 Publication Date 10/6/2020 
Target
Name:
Amino acid transporter
Synonyms:
Amino acid transporter | Slc1a5
Type:
PROTEIN
Mol. Mass.:
56758.53
Organism:
Rattus norvegicus
Description:
ChEMBL_109757
Residue:
539
Sequence:
MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRDQVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPLPLATEEGNPLLKQCREPSGDSSATCEKESVM
  
Inhibitor
Name:
BDBM464401
Synonyms:
US10793514, Compound 5
Type:
Small organic molecule
Emp. Form.:
C32H34N2O6
Mol. Mass.:
542.6222
SMILES:
COc1cccc(Oc2ccccc2CN(CC[C@@H](N)C(O)=O)Cc2ccccc2Oc2ccccc2OC)c1 |r|
Structure:
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