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Target
WD repeat-containing protein 5
Ligand
BDBM468937
Substrate
n/a
Meas. Tech.
FPA Binding Assay
Ki
0.097±n/a nM
Citation
 Gogliotti, RD; Stauffer, SR; Jeon, K; Salovich, JM; Macdonald, JD; Mills, JJ; Meyers, KM; Alvarado, JR; Han, C; Fesik, SW; Lee, T WDR5-MLL1 inhibitors and modulators US Patent  US10807959 Publication Date 10/20/2020 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM468937
Synonyms:
US10807959, Example B107
Type:
Small organic molecule
Emp. Form.:
C26H28FN5O3
Mol. Mass.:
477.5306
SMILES:
COc1ccc(CNC(=O)c2cc(CNC3=NCCN3)cc(c2)-c2cc(C)cnc2F)cc1OC |t:15|
Structure:
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