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Target
Methionine aminopeptidase 2
Ligand
BDBM468976
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay of MetAP2
IC50
32.1±6.2 nM
Citation
 Ho, KK; Quan, W; Zhou, J Pyrrolidinone compounds US Patent  US10807971 Publication Date 10/20/2020 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
MAP2_MOUSE | Metap2 | Methionine aminopeptidase Type 2 (MetAP2) | Mnpep | P67eif2 | Peptidase M 2
Type:
Enzyme
Mol. Mass.:
52914.64
Organism:
Mus musculus (Mouse)
Description:
O08663
Residue:
478
Sequence:
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM468976
Synonyms:
(3S)-1-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tetrahydropyran-3-yl]pyrazol-3-yl]-N-[(3-chloro-5-fluoro-phenyl)methyl]-3-hydroxy-2-oxo-pyrrolidine-3-carboxamide, hydrochloride | US10807971, Example 12
Type:
Small organic molecule
Emp. Form.:
C26H25ClF3N5O4
Mol. Mass.:
563.956
SMILES:
N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Structure:
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