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Target
Nociceptin receptor
Ligand
BDBM469355
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469355
Synonyms:
US10807988, Example SC_3006 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-2-methylsulfonyl-pyrimidine-4-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C27H34N6O3S
Mol. Mass.:
522.662
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2C#N)S(C)(=O)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(6.83,9.12,;5.29,9.12,;4.52,10.45,;4.52,7.78,;3.75,6.45,;2.21,6.45,;1.44,7.78,;.53,9.03,;-.93,8.55,;-.93,7.01,;-2.18,6.11,;.53,6.54,;1.01,5.07,;-.02,3.93,;-1.56,3.93,;-1.56,2.39,;-.02,2.39,;-2.26,9.32,;-3.6,8.55,;-4.93,9.32,;-4.93,10.86,;-3.6,11.63,;-2.26,10.86,;-.93,11.63,;.4,12.4,;-6.27,11.63,;-6.27,10.09,;-6.27,13.17,;-7.6,10.86,;2.21,9.12,;3.75,9.12,;5.29,6.45,;4.52,5.11,;5.29,3.78,;6.83,3.78,;7.6,5.11,;6.83,6.45,)|
Structure:
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