Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469358
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469358
Synonyms:
US10807988, Example SC_3009 | cis-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C28H36N4O2
Mol. Mass.:
460.611
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ccccc2C(N)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(5.12,23,;3.58,23,;2.81,24.34,;2.81,21.67,;2.04,20.34,;.5,20.34,;-.27,21.67,;-1.18,22.92,;-2.64,22.44,;-2.64,20.9,;-3.89,20,;-1.18,20.42,;-.7,18.96,;-1.73,17.82,;-3.27,17.82,;-3.27,16.28,;-1.73,16.28,;-3.89,23.35,;-5.29,22.72,;-6.54,23.62,;-6.38,25.16,;-4.97,25.78,;-3.73,24.88,;-2.32,25.5,;-2.16,27.04,;-1.07,24.6,;.5,23,;2.04,23,;3.58,20.34,;2.81,19,;3.58,17.67,;5.12,17.67,;5.89,19,;5.12,20.34,)|
Structure:
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