Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469376
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.400±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469376
Synonyms:
US10807988, Example SC_3022 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl-3-[2-(trifluoromethyl)- pyrimidin-5-yl]-1,3-diazaspiro[4.51decan-2-one
Type:
Small organic molecule
Emp. Form.:
C26H32F3N5O
Mol. Mass.:
487.5604
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.39,8.81,;5.16,7.47,;6.7,7.47,;4.39,6.14,;3.62,4.81,;2.08,4.81,;1.31,6.14,;.41,7.38,;-1.06,6.91,;-1.06,5.37,;-2.31,4.46,;.41,4.89,;.88,3.43,;-.15,2.28,;-1.69,2.28,;-1.69,.74,;-.15,.74,;-2.39,7.68,;-2.39,9.22,;-3.73,9.99,;-5.06,9.22,;-5.06,7.68,;-3.73,6.91,;-6.39,9.99,;-7.73,9.22,;-6.39,11.53,;-7.73,10.76,;2.08,7.47,;3.62,7.47,;5.16,4.81,;4.39,3.47,;5.16,2.14,;6.7,2.14,;7.47,3.47,;6.7,4.81,)|
Structure:
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