Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469378
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469378
Synonyms:
US10807988, Example SC_3024 | cis-5-[8-Dimethylamino-1-(2-methyl-propy1)-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrimidine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C25H32N6O
Mol. Mass.:
432.5612
SMILES:
CC(C)CN1C(=O)N(C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1)c1cnc(nc1)C#N |r,wU:9.9,12.16,(.13,-25.61,;-.34,-24.14,;-1.85,-23.82,;.69,-23,;.21,-21.53,;-1.25,-21.06,;-2.5,-21.96,;-1.25,-19.52,;.21,-19.04,;1.12,-20.29,;1.89,-21.62,;3.43,-21.62,;4.2,-20.29,;3.43,-18.95,;1.89,-18.95,;4.97,-18.95,;4.2,-17.62,;6.51,-18.95,;4.97,-21.62,;4.2,-22.95,;4.97,-24.29,;6.51,-24.29,;7.28,-22.95,;6.51,-21.62,;-2.5,-18.61,;-2.34,-17.08,;-3.58,-16.18,;-4.99,-16.8,;-5.15,-18.33,;-3.91,-19.24,;-6.24,-15.9,;-7.48,-14.99,)|
Structure:
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