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Target
Mu-type opioid receptor
Ligand
BDBM469398
Substrate
n/a
Meas. Tech.
Human Mu-Opioid Peptide (hMOP) Receptor Binding Assay
Ki
79.5±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM469398
Synonyms:
US10807988, Example SC_3041 | cis-5-[1-[(1-Cyano-cyclobutyl)-methyl]-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-pyrimidine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C27H31N7O
Mol. Mass.:
469.5813
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(CCC2)C#N)c2cnc(nc2)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(3.2,23.24,;3.97,21.91,;5.51,21.91,;3.2,20.58,;2.43,19.24,;.89,19.24,;.12,20.58,;-.79,21.82,;-2.25,21.35,;-2.25,19.81,;-3.5,18.9,;-.79,19.33,;-.31,17.87,;-1.34,16.72,;-2.88,16.64,;-2.8,15.1,;-1.26,15.18,;.14,16.32,;1.63,15.92,;-3.5,22.25,;-3.34,23.78,;-4.58,24.69,;-5.99,24.06,;-6.15,22.53,;-4.91,21.62,;-7.24,24.97,;-8.33,26.06,;.89,21.91,;2.43,21.91,;3.97,19.24,;3.2,17.91,;3.97,16.57,;5.51,16.57,;6.28,17.91,;5.51,19.24,)|
Structure:
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