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Target
Nociceptin receptor
Ligand
BDBM469437
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.600±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469437
Synonyms:
US10807988, Example SC_3078 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-4-methyl-pyridine-2-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C28H35N5O
Mol. Mass.:
457.6104
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(cc2C)C#N)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.01,24.08,;4.78,22.75,;6.32,22.75,;4.01,21.41,;3.24,20.08,;1.7,20.08,;.93,21.41,;.03,22.66,;-1.44,22.18,;-1.44,20.64,;-2.68,19.74,;.03,20.17,;.5,18.7,;-.53,17.56,;-2.07,17.56,;-2.07,16.02,;-.53,16.02,;-2.53,23.27,;-4.01,22.87,;-5.1,23.96,;-4.7,25.45,;-3.22,25.85,;-2.13,24.76,;-.64,25.16,;-5.79,26.54,;-6.88,27.63,;1.7,22.75,;3.24,22.75,;4.78,20.08,;4.01,18.74,;4.78,17.41,;6.32,17.41,;7.09,18.74,;6.32,20.08,)|
Structure:
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