Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469443
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.80±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469443
Synonyms:
US10807988, Example SC_3084 | cis-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-methylsulfonyl-4- (trifluoromethyl)-phenyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C29H36F3N3O3S
Mol. Mass.:
563.675
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2ccc(cc2S(C)(=O)=O)C(F)(F)F)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.18,-2.97,;4.95,-4.3,;6.49,-4.3,;4.18,-5.63,;3.41,-6.97,;1.87,-6.97,;1.1,-5.63,;.19,-4.39,;-1.27,-4.86,;-1.27,-6.4,;-2.52,-7.31,;.19,-6.88,;.67,-8.34,;-.36,-9.49,;-1.9,-9.49,;-1.9,-11.03,;-.36,-11.03,;-2.36,-3.78,;-3.85,-4.17,;-4.94,-3.08,;-4.54,-1.6,;-3.05,-1.2,;-1.96,-2.29,;-.47,-1.89,;.62,-2.98,;-.87,-.4,;.62,-.8,;-5.63,-.51,;-7.11,-.91,;-5.23,.98,;-6.71,.58,;1.87,-4.3,;3.41,-4.3,;4.95,-6.97,;4.18,-8.3,;4.95,-9.64,;6.49,-9.64,;7.26,-8.3,;6.49,-6.97,)|
Structure:
Search PDB for entries with ligand similarity: