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Target
Nociceptin receptor
Ligand
BDBM469445
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469445
Synonyms:
US10807988, Example SC_3086 | cis-1-(Cyclobutyl-methyl)-3-(2,4-dimethoxy-phenyl)-8-dimethylamino-8-phenyl- 1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C29H39N3O3
Mol. Mass.:
477.6383
SMILES:
COc1ccc(N2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c(OC)c1 |r,wU:8.24,11.14,(-7.92,25.09,;-6.58,25.86,;-5.25,25.09,;-5.25,23.55,;-3.92,22.78,;-2.58,23.55,;-1.25,22.78,;.16,23.41,;1.19,22.26,;2.09,21.02,;3.62,21.18,;4.25,22.58,;3.35,23.83,;1.81,23.67,;4.88,23.99,;6.41,24.15,;3.97,25.24,;5.34,21.49,;4.94,20.01,;6.03,18.92,;7.52,19.32,;7.92,20.8,;6.83,21.89,;.42,20.93,;1.04,19.52,;.14,18.28,;-1.38,18.03,;-1.14,16.51,;.38,16.75,;-1.09,21.25,;-2.23,20.22,;-2.58,25.09,;-1.25,25.86,;.08,25.09,;-3.92,25.86,)|
Structure:
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