Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469456
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469456
Synonyms:
US10807988, Example SC_3098 | cis-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-[2-(4-methyl-piperazin- 1-yl)-pyrimidin-5-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C30H43N7O2
Mol. Mass.:
533.7081
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)c2cnc(nc2)N2CCN(C)CC2)CC1)c1ccccc1 |r,wU:6.11,3.2,(5.3,-18.99,;6.07,-20.32,;7.61,-20.32,;5.3,-21.66,;4.53,-22.99,;2.99,-22.99,;2.22,-21.66,;1.32,-20.41,;-.15,-20.89,;-.15,-22.43,;-1.39,-23.33,;1.32,-22.9,;1.79,-24.37,;.76,-25.51,;2.25,-25.91,;-.78,-25.51,;-.78,-27.05,;.76,-27.05,;-1.32,-19.89,;-2.77,-20.41,;-3.95,-19.42,;-3.68,-17.9,;-2.23,-17.38,;-1.05,-18.38,;-4.85,-16.91,;-4.58,-15.4,;-5.76,-14.4,;-7.21,-14.92,;-8.38,-13.93,;-7.48,-16.44,;-6.3,-17.43,;2.99,-20.32,;4.53,-20.32,;6.07,-22.99,;5.3,-24.32,;6.07,-25.66,;7.61,-25.66,;8.38,-24.32,;7.61,-22.99,)|
Structure:
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