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Target
Nociceptin receptor
Ligand
BDBM469465
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469465
Synonyms:
US10807988, Example SC_3105 | cis-1-(Cyclopropyl-methyl)-8-dimethylamino-3-(4-methylsulfonyl-phenyl)-8- phenyl-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C26H34N4O3S
Mol. Mass.:
482.638
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2CC2)c2ccc(nc2)S(C)(=O)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(4.05,23.45,;4.82,22.12,;6.36,22.12,;4.05,20.79,;3.28,19.45,;1.74,19.45,;.97,20.79,;.07,22.03,;-1.4,21.56,;-1.4,20.02,;-2.64,19.11,;.07,19.54,;.54,18.08,;-.49,16.93,;-1.95,16.46,;-.81,15.43,;-2.73,22.33,;-2.73,23.87,;-4.06,24.64,;-5.4,23.87,;-5.4,22.33,;-4.06,21.56,;-6.73,24.64,;-6.73,26.18,;-8.27,24.64,;-7.5,23.3,;1.74,22.12,;3.28,22.12,;4.82,19.45,;4.05,18.12,;4.82,16.79,;6.36,16.79,;7.13,18.12,;6.36,19.45,)|
Structure:
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