Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469577
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469577
Synonyms:
US10807988, Example SC_3207 | US10807988, Example SC_3208 | cis-3-(1,3-Benzodioxol-4-yl)-8-dimethylamino-8-phenyl-1,3-diazaspiro[4.5]decan- 2-one
Type:
Small organic molecule
Emp. Form.:
C28H30N6O2
Mol. Mass.:
482.5768
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(nc2)-c2cccc3NC(=O)Cc23)CC1)c1ccccc1 |r,wU:6.11,3.2,(3.8,8.92,;4.57,7.58,;6.11,7.58,;3.8,6.25,;3.03,4.92,;1.49,4.92,;.72,6.25,;-.19,7.5,;-1.65,7.02,;-1.65,5.48,;-2.9,4.58,;-.19,5,;-2.74,8.11,;-2.34,9.6,;-3.43,10.69,;-4.92,10.29,;-5.32,8.8,;-4.23,7.71,;-6.01,11.38,;-7.5,10.98,;-8.59,12.07,;-8.19,13.55,;-6.7,13.95,;-6,15.32,;-4.48,15.08,;-3.39,16.17,;-4.24,13.56,;-5.61,12.86,;1.49,7.58,;3.03,7.58,;4.57,4.92,;3.8,3.58,;4.57,2.25,;6.11,2.25,;6.88,3.58,;6.11,4.92,)|
Structure:
Search PDB for entries with ligand similarity: