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Target
Nociceptin receptor
Ligand
BDBM469718
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
2.00±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469718
Synonyms:
US10807988, Example SC_3354 | cis-4-[5-(8-Dimethylamino-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl)- pyrimidin-2-yl]-benzamide; 2,2,2-trifluoro-acetic acid
Type:
Small organic molecule
Emp. Form.:
C27H30N6O2
Mol. Mass.:
470.5661
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2)c2cnc(nc2)-c2ccc(cc2)C(N)=O)CC1)c1ccccc1 |r,wU:6.11,3.2,(-4.44,-28.17,;-4.04,-29.66,;-2.56,-30.06,;-5.13,-30.75,;-5.68,-32.18,;-7.21,-32.43,;-8.17,-31.23,;-9.26,-30.14,;-10.64,-30.84,;-10.4,-32.36,;-11.48,-33.45,;-8.87,-32.6,;-11.97,-30.07,;-11.97,-28.53,;-13.3,-27.76,;-14.64,-28.53,;-14.64,-30.07,;-13.3,-30.84,;-15.97,-27.76,;-15.97,-26.22,;-17.3,-25.45,;-18.64,-26.22,;-18.64,-27.76,;-17.3,-28.53,;-19.97,-25.45,;-21.31,-26.22,;-19.97,-23.91,;-7.62,-29.79,;-6.1,-29.55,;-3.8,-31.52,;-3.8,-33.06,;-2.47,-33.83,;-1.13,-33.06,;-1.13,-31.52,;-2.47,-30.75,)|
Structure:
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