Reaction Details Report a problem with these data
Target
ADAMTS5
Ligand
BDBM471794
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
12.5±n/a nM
Citation
 Labéguère, FG; Heng, R; De Ceuninck, FA; Alvey, LJ; Amantini, D; Brebion, FL; Deprez, PM; Gosmini, RL; Jary, HM; Peixoto, C; Pop-Botez, IE; Varin, ML 5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis US Patent  US10829478 Publication Date 11/10/2020 
Target
Name:
ADAMTS5
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
101844.10
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
928
Sequence:
MLLEWASLLLLLLLLCASCLALAADNPAAAPAQDKTRQPRAAAAAAQPDQRQWEETQERGHPQPLARQRRSSGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDTVGAAGGIVTAGGGLSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAESERVYGDGSSRILHVYTREGFSFEALPPRTSCETPASPSGPQESPSVHSSSRRRTELAPQLLDHSAFSPAGNAGPQTWWRRRRRSISRARQVELLLVADSSMAKMYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLTDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDVPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSVIPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIIGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKTTQKVNSVISHSSNKVGLHSPQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCILSQRPSAFKQCLLKKC
  
Inhibitor
Name:
BDBM471794
Synonyms:
5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperazin-1- yl]-2-methyl-3- oxo-propyl]-5- methyl- imidazolidine- 2,4-dione | US10829478, Compound 43
Type:
Small organic molecule
Emp. Form.:
C19H24F2N4O4
Mol. Mass.:
410.4151
SMILES:
COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r|
Structure:
Search PDB for entries with ligand similarity: