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Target
BH3-interacting domain death agonist [79-99]
Ligand
BDBM472688
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
>5000±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors US Patent  US10829488 Publication Date 11/10/2020 
Target
Name:
BH3-interacting domain death agonist [79-99]
Synonyms:
BH3-interacting domain death agonist (BID)(79-99) | BID | BID_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
2437.19
Organism:
Homo sapiens (Human)
Description:
aa 79-99
Residue:
21
Sequence:
QEDIIRNIARHLAQVGDSMDR
  
Inhibitor
Name:
BDBM472688
Synonyms:
(R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)-2- oxaspiro[3.5]non-6-en-7-yl)methyl)piperazin-1- yl)benzamide | US10829488, Cpd. No. 8
Type:
Small organic molecule
Emp. Form.:
C44H46ClN7O9S
Mol. Mass.:
884.396
SMILES:
[O-][N+](=O)c1cc(ccc1NC[C@@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(COC3)CC2)c2ccc(Cl)cc2)CC1 |r,t:49|
Structure:
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