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Target
Bcl-2-like protein 11 [72-87]
Ligand
BDBM361585
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
3.80±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors US Patent  US10829488 Publication Date 11/10/2020 
Target
Name:
Bcl-2-like protein 11 [72-87]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2 homologous antagonist/killer (BAK)(72-87)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
1724.92
Organism:
Homo sapiens (Human)
Description:
aa 72-87
Residue:
16
Sequence:
GQVGRQLAIIGDDINR
  
Inhibitor
Name:
BDBM361585
Synonyms:
2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4- ((6-(4-chlorophenyl)spiro[3.5]non-6-en-7- yl)methyl)piperazin-1-yl)-N-((2-isopropyl-7- nitro-1H-benzo[d]imidazol-5- yl)sulfonyl)benzamide | US10221174, Compound 58 | US10829488, Compound 58 | US11718613, Compound 58
Type:
Small organic molecule
Emp. Form.:
C44H45ClN8O6S
Mol. Mass.:
849.396
SMILES:
CC(C)c1nc2cc(cc([N+]([O-])=O)c2[nH]1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |t:47|
Structure:
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