Reaction Details Report a problem with these data
Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) -44,87-209]
Ligand
BDBM50424725
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
3300±n/a nM
Citation
 Lee, T; Pelz, NF; Belmar, J; Bian, Z; Olejniczak, ET; Fesik, SW; Chauder, BA Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors US Patent  US10844032 Publication Date 11/24/2020 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) -44,87-209]
Synonyms:
B2CL1_HUMAN | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) [1-44,87-209] | Bcl-2-like protein 1 Isoform Bcl-X(L) (aa 1-44, aa 87-209)
Type:
n/a
Mol. Mass.:
18986.66
Organism:
Human
Description:
n/a
Residue:
166
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER
  
Inhibitor
Name:
BDBM50424725
Synonyms:
CHEMBL2314177 | US10093640, Example 5 | US10844032, Example 5
Type:
Small organic molecule
Emp. Form.:
C22H17ClO3S
Mol. Mass.:
396.887
SMILES:
OC(=O)c1sc2cc(Cl)ccc2c1CCCOc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: