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Target
WD repeat-containing protein 5
Ligand
BDBM473444
Substrate
n/a
Meas. Tech.
TR-FRET Binding Assay
Ki
0.100±n/a nM
Citation
 Alvarado, JR; Stauffer, SR; Gogliotti, RD; Han, C; Meyers, KM; Tian, J; Macdonald, JD; Fesik, SW; Lee, T WDR5 inhibitors and modulators US Patent  US10844044 Publication Date 11/24/2020 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM473444
Synonyms:
US10844044, Example 63
Type:
Small organic molecule
Emp. Form.:
C31H31F3N4O4
Mol. Mass.:
580.5974
SMILES:
COc1cc(OC)cc(c1)C(NC(=O)c1cc(Cn2ccn(C)c2=N)cc(c1)-c1ccc(F)cc1OC(F)F)C1CC1
Structure:
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