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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM50158324
Substrate
n/a
Meas. Tech.
fluorescence polarization competition assay (FPCA)
Ki
300±40 nM
Citation
 Fletcher, S; Lanning, M; Chen, L Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof US Patent  US10858316 Publication Date 12/8/2020 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50158324
Synonyms:
CHEMBL3780311 | US10858316, Compound 3be
Type:
Small organic molecule
Emp. Form.:
C23H16BrNO6S
Mol. Mass.:
514.345
SMILES:
OC(=O)c1cc(c2ccccc2c1O)S(=O)(=O)Nc1ccc(Oc2cccc(Br)c2)cc1
Structure:
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