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Target
Adenosine receptor A2a
Ligand
BDBM474292
Substrate
n/a
Meas. Tech.
FLIPR and cAMP Inhibition Assay
IC50
0.900±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US10858365 Publication Date 12/8/2020 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_MOUSE | Adenosine A2a receptor | Adenosine receptor A2a | Adora2a
Type:
PROTEIN
Mol. Mass.:
44984.04
Organism:
Mus musculus
Description:
ChEMBL_479903
Residue:
410
Sequence:
MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
  
Inhibitor
Name:
BDBM474292
Synonyms:
5-(5-am i no-2-(2,6-difluorobenzy1)-7-(oxazol-2- yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl)-l- isopropylpyrdin-2(1H)-one | US10858365, Compound 79
Type:
Small organic molecule
Emp. Form.:
C23H19F2N7O2
Mol. Mass.:
463.4395
SMILES:
CC(C)n1cc(ccc1=O)-c1c(nc(N)n2nc(Cc3c(F)cccc3F)nc12)-c1ncco1
Structure:
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