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Target
Protein Wnt-3a
Ligand
BDBM300468
Substrate
n/a
Meas. Tech.
HCT116 TOPFlash Assay
IC50
27.5±n/a nM
Citation
 Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent  US10130633 Publication Date 11/20/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM300468
Synonyms:
3-({[1-(4-cyclopropylpiperazin-1-yl)cyclopropyl]carbonyl}amino)-4-(difluoromethoxy)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide | US10130633, Example 38
Type:
Small organic molecule
Emp. Form.:
C27H28F2N6O3S
Mol. Mass.:
554.611
SMILES:
FC(F)Oc1ccc(cc1NC(=O)C1(CC1)N1CCN(CC1)C1CC1)C(=O)Nc1nnc(s1)-c1ccccc1 |$;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;$|
Structure:
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