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Target
Protein Wnt-3a
Ligand
BDBM300440
Substrate
n/a
Meas. Tech.
HCT116 TOPFlash Assay
IC50
10.4±n/a nM
Citation
 Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent  US10130633 Publication Date 11/20/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM300440
Synonyms:
3-{[2-(morpholin-4-yl)propanoyl]amino}-N-(6-phenylpyridin-3-yl)-4-(trifluoromethoxy)benzamide | US10130633, Example 10 | US10130633, Example 208
Type:
Small organic molecule
Emp. Form.:
C26H25F3N4O4
Mol. Mass.:
514.4963
SMILES:
CC(N1CCOCC1)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1ccccc1 |$;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;$|
Structure:
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