Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM300673
Substrate
n/a
Meas. Tech.
HCT116 TOPFlash Assay
IC50
28.0±n/a nM
Citation
 Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent  US10130633 Publication Date 11/20/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM300673
Synonyms:
N-[6-(3-fluorophenyl)pyridin-3- yl]-3-({(2R*)-2-[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]hept-5- yl]propanoyl}amino)-4- (trifluoromethoxy)benzamide | US10130633, Example 243 | US10130633, Example 244
Type:
Small organic molecule
Emp. Form.:
C27H24F4N4O4
Mol. Mass.:
544.4975
SMILES:
CC(N1C[C@@H]2C[C@H]1CO2)C(=O)Nc1cc(ccc1OC(F)(F)F)C(=O)Nc1ccc(nc1)-c1cccc(F)c1 |r|
Structure:
Search PDB for entries with ligand similarity: