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Target
Protein Wnt-3a
Ligand
BDBM300436
Substrate
n/a
Meas. Tech.
HEK TOP OncoFlash Assay
IC50
13.0±n/a nM
Citation
 Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent  US10130633 Publication Date 11/20/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM300436
Synonyms:
N-[6-(2-fluorophenyl)pyridin-3-yl]-3-[(8-oxa-3-azabicyclo[3.2.1]oct-3-ylacetyl)amino]-4-(trifluoromethoxy)benzamide | US10130633, Example 6
Type:
Small organic molecule
Emp. Form.:
C27H24F4N4O4
Mol. Mass.:
544.4975
SMILES:
Fc1ccccc1-c1ccc(NC(=O)c2ccc(OC(F)(F)F)c(NC(=O)CN3CC4CCC(C3)O4)c2)cn1 |$;;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure:
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