Reaction Details Report a problem with these data
Target
ADP-ribosylation factor 6
Ligand
BDBM475066
Substrate
n/a
Meas. Tech.
Biochemical Assay1
IC50
1.40±n/a nM
Citation
 Ostanin, K; Shenderovich, M; Bajji, A; Cioffi, CL; Moss, N; Vankayalapati, H; Li, D Arf6 inhibitors and methods of synthesis and use thereof US Patent  US10849901 Publication Date 12/1/2020 
Target
Name:
ADP-ribosylation factor 6
Synonyms:
ARF6 | ARF6_HUMAN
Type:
Protein
Mol. Mass.:
20087.47
Organism:
Human
Description:
P62330
Residue:
175
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
  
Inhibitor
Name:
BDBM475066
Synonyms:
US10849901, Compound 116
Type:
Small organic molecule
Emp. Form.:
C25H23N3O4S2
Mol. Mass.:
493.598
SMILES:
CCOc1ccc(cc1C)-c1nn(cc1\C=C1/SC(=S)N(CCC(O)=O)C1=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: