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Target
Ubiquitin-like modifier-activating enzyme ATG7
Ligand
BDBM476146
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
35±n/a nM
Citation
 Adhikari, S; Calderwood, EF; England, DB; Gould, AE; Harrison, SJ; Huang, S; Ma, L ATG7 inhibitors and the uses thereof US Patent  US10865208 Publication Date 12/15/2020 
Target
Name:
Ubiquitin-like modifier-activating enzyme ATG7
Synonyms:
APG7-like | APG7L | ATG12-activating enzyme E1 ATG7 | ATG7 | ATG7_HUMAN | Autophagy-related protein 7 | Ubiquitin-activating enzyme E1-like protein | hAGP7
Type:
PROTEIN
Mol. Mass.:
77955.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939703
Residue:
703
Sequence:
MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI
  
Inhibitor
Name:
BDBM476146
Synonyms:
US10865208, Compound I-201 | {(2R,3S,5R)-5-[4-amino-3-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)-1H- pyrazolo[3,4-d]pyrimidin-1-yl]-3-hydroxytetrahydrofuran-2-yl}methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C18H20N6O7S2
Mol. Mass.:
496.517
SMILES:
Nc1ncnc2n(nc(Sc3ccc4OCCOc4c3)c12)[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)O1 |r|
Structure:
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