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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM372152
Substrate
n/a
Meas. Tech.
RIPK2 Inhibition Assay
IC50
>500±n/a nM
Citation
 Laufer, R; Ng, G; Brokx, R; Pauls, HW; Li, S; Mason, JM; Bray, MR RIPK2 inhibitors and method of treating cancer with same US Patent  US10875863 Publication Date 12/29/2020 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM372152
Synonyms:
2-(4-(2-methyl- 6-((6- (o-tolyl)-5H- pyrrolo[3,2- d]pyrimidin-2- yl)amino)pyrimidin- 4-yl)piperazin-1- yl)ethanol | US10239881, Example A5 | US10875863, Example A5
Type:
Small organic molecule
Emp. Form.:
C24H28N8O
Mol. Mass.:
444.5321
SMILES:
Cc1nc(Nc2ncc3[nH]c(cc3n2)-c2ccccc2C)cc(n1)N1CCN(CCO)CC1
Structure:
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