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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM372165
Substrate
n/a
Meas. Tech.
RIPK2 Inhibition Assay
IC50
<100±n/a nM
Citation
 Laufer, R; Ng, G; Brokx, R; Pauls, HW; Li, S; Mason, JM; Bray, MR RIPK2 inhibitors and method of treating cancer with same US Patent  US10875863 Publication Date 12/29/2020 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM372165
Synonyms:
N-(4-((4- methylpiperazin-1- yl)methyl)phenyl)- 6-(o-tolyl)-5H- pyrrolo[3,2-d] pyrimidin-2-amine | US10239881, Example A18 | US10875863, Example A18
Type:
Small organic molecule
Emp. Form.:
C25H28N6
Mol. Mass.:
412.53
SMILES:
CN1CCN(Cc2ccc(Nc3ncc4[nH]c(cc4n3)-c3ccccc3C)cc2)CC1
Structure:
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