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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242352
Substrate
n/a
Meas. Tech.
Pim-1 Kinase Inhibition Assay
IC50
4.00±n/a nM
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, MD; Ho, K Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors US Patent  US10875864 Publication Date 12/29/2020 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242352
Synonyms:
US10047093, 8-8 | US10392392, Example 8-8 | US10875864, EX. 8-8 | US9416132, 8-8
Type:
Small organic molecule
Emp. Form.:
C19H20F3N5O
Mol. Mass.:
391.3902
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:4.7,wD:1.0,(-8.57,3.62,;-7.24,2.85,;-7.24,1.31,;-5.91,.54,;-4.57,1.31,;-4.57,2.85,;-5.91,3.62,;-3.24,.54,;-1.91,1.31,;-1.91,2.85,;-.57,3.62,;.76,2.85,;2.23,3.33,;3.13,2.08,;2.23,.84,;2.62,-.65,;1.54,-1.74,;1.93,-3.23,;3.42,-3.62,;4.56,-2.55,;6.05,-2.95,;7.14,-1.86,;8.23,-.77,;8.23,-2.95,;6.05,-.77,;4.11,-1.05,;.76,1.31,;-.57,.54,)|
Structure:
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