Reaction Details Report a problem with these data
Target
Receptor activity-modifying protein 1
Ligand
BDBM391716
Substrate
n/a
Meas. Tech.
Radioligand binding assay
Ki
0.020±n/a nM
Citation
 Christopher, JA; Congreve, MS; Bucknell, SJ; Deflorian, F; Pickworth, M; Mason, JS CGRP receptor antagonists US Patent  US10888561 Publication Date 1/12/2021 
Target
Name:
Receptor activity-modifying protein 1
Synonyms:
Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN
Type:
PROTEIN
Mol. Mass.:
16992.80
Organism:
Homo sapiens (Human)
Description:
EBI_100673
Residue:
148
Sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
  
Inhibitor
Name:
BDBM391716
Synonyms:
N-[(2R)-3-(7-methyl-1H- | US10300056, Example 1 | US10888561, Example 1
Type:
Small organic molecule
Emp. Form.:
C40H50N12O4
Mol. Mass.:
762.903
SMILES:
Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)n2c3cccnc3[nH]c2=O)C(=O)N[C@@H](CC2CCNCC2)C(=O)N2CCN(CC2)c2ccncc2)cc2cn[nH]c12 |r|
Structure:
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