Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM479507
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
2.90±n/a nM
Citation
 Qi, C; Tsui, H; Zeng, Q; Yang, Z; Zhang, X Pyrazine compounds and uses thereof US Patent  US10898481 Publication Date 1/26/2021 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM479507
Synonyms:
3-amino-6-(1-methyl-6-oxo-1,6- dihydropyridin-3-yl)-N-((6- (methylamino)pyridin-2-yl)methyl)- 5-(oxazol-2-yl) pyrazine-2-carboxamide | US10898481, Compound 23 | US11571420, Compound 23
Type:
Small organic molecule
Emp. Form.:
C21H20N8O3
Mol. Mass.:
432.4353
SMILES:
CNc1cccc(CNC(=O)c2nc(-c3ccc(=O)n(C)c3)c(nc2N)-c2ncco2)n1
Structure:
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