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Target
Tyrosine-protein kinase BTK
Ligand
BDBM480094
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<1.000±n/a nM
Citation
Hopkins, BT; Ma, B; Prince, R; Marx, I; Schulz, J; Nevalainen, M; Dechantsreiter, M Inhibiting agents for Bruton's tyrosine kinase US Patent US10899753 Publication Date 1/26/2021
More Info.:
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Inhibitor
Name:
BDBM480094
Synonyms:
3-(tert-butyl)-N-(2-chloro-3-fluoro-4-(4-((1-methyl-1H-pyrazol-3-yl)amino)-1,3,5-triazin-2-yl)benzyl)-1,2,4-oxadiazole-5-carboxamide | US10899753, Example 22
Type:
Small organic molecule
Emp. Form.:
C21H21ClFN9O2
Mol. Mass.:
485.902
SMILES:
Cn1ccc(Nc2ncnc(n2)-c2ccc(CNC(=O)c3nc(no3)C(C)(C)C)c(Cl)c2F)n1