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Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM480552
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
2.00±n/a nM
Citation
 Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent  US10899769 Publication Date 1/26/2021 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM480552
Synonyms:
US10899769, Example 36a
Type:
Small organic molecule
Emp. Form.:
C27H27F3N6O2
Mol. Mass.:
524.5375
SMILES:
C[C@@H]1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2nc(-c3cnn(C)c3)c(cc12)C(F)F |r,wU:1.0,(7.53,-.11,;7.53,1.43,;8.86,2.2,;10.2,1.43,;8.86,3.74,;10.2,4.51,;7.53,4.51,;6.2,3.74,;4.73,4.21,;3.83,2.97,;4.73,1.72,;4.25,.25,;5.29,-.89,;4.81,-2.35,;3.3,-2.67,;2.27,-1.53,;2.75,-.07,;6.2,2.2,;4.25,5.68,;5.29,6.82,;6.79,6.5,;4.81,8.28,;3.3,8.6,;2.27,7.46,;.77,7.78,;-.26,6.64,;-1.77,6.96,;-2.91,5.93,;-4.25,6.7,;-3.93,8.2,;-4.96,9.35,;-2.4,8.36,;.21,5.17,;1.72,4.85,;2.75,6,;-.82,4.03,;-.34,2.56,;-2.33,4.35,)|
Structure:
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