Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM480559
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
6.00±n/a nM
Citation
 Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent  US10899769 Publication Date 1/26/2021 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM480559
Synonyms:
1-(6-Fluoro-1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-5,7-dimethyl-3-(tetrahydro-2H-pyran-4-yl)-7,8-dihydroimidazo[1,5-a]pyrazin-6(5H)-one 2,2,2-trifluoroacetate | US10899769, Example 43
Type:
Small organic molecule
Emp. Form.:
C25H28FN7O2
Mol. Mass.:
477.5339
SMILES:
CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cc2c(nn(C)c2cc1F)-c1cnn(C)c1
Structure:
Search PDB for entries with ligand similarity: