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Target
Bromodomain-containing protein 4 [49-170]
Ligand
BDBM480611
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
3.00±n/a nM
Citation
 Le, K; Soth, MJ; Liu, G; Jones, P; Cross, JB; Mcafoos, TJ; Carroll, CL; Lewis, RT Imidazopiperazinone inhibitors of transcription activating proteins US Patent  US10899769 Publication Date 1/26/2021 
Target
Name:
Bromodomain-containing protein 4 [49-170]
Synonyms:
BRD4 | BRD4-BD1 | BRD4-BD1 (aa 49-170) | BRD4_HUMAN | Bromodomain containing 4 (aa 49-170) | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(49-170) | Bromodomain-containing protein 4 (BRD4)(BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14593.14
Organism:
Homo sapiens (Human)
Description:
aa 49-170 (BRD4-BD1)
Residue:
122
Sequence:
ETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETE
  
Inhibitor
Name:
BDBM480611
Synonyms:
1-(3-(1,3-dimethyl-1H- pyrazol-4-yl)-7- fluoroisoquinolin-8-yl)-5,7- dimethyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5-a] pyrazin-6(5H)-one | US10899769, Example 91a | US10899769, Example 91b
Type:
Small organic molecule
Emp. Form.:
C27H29FN6O2
Mol. Mass.:
488.5566
SMILES:
CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1cn(C)nc1C |(.6,5.86,;.13,4.39,;-1.38,4.07,;-2.41,5.21,;-1.86,2.61,;-3.34,2.21,;-.82,1.46,;.68,1.78,;1.93,.88,;3.17,1.78,;2.7,3.25,;3.47,4.58,;5.01,4.58,;5.78,5.91,;5.01,7.25,;3.47,7.25,;2.7,5.91,;1.16,3.25,;1.93,-.66,;3.26,-1.43,;4.59,-.66,;3.26,-2.97,;1.93,-3.74,;.59,-2.97,;-.74,-3.74,;-2.07,-2.97,;-2.07,-1.43,;-.74,-.66,;.59,-1.43,;-3.41,-3.74,;-3.41,-5.28,;-4.87,-5.76,;-5.27,-7.25,;-5.78,-4.51,;-4.87,-3.27,;-5.27,-1.78,)|
Structure:
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