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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM480743
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
1.60±n/a nM
Citation
 Bryan, MC; Drobnick, J; Gobbi, A; Katsumoto, T; Rajapaksa, NS; Kiefer, Jr., JR IRAK4 modulators US Patent  US10899774 Publication Date 1/26/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM480743
Synonyms:
N-(2,2-dimethyl-6-morpholino- 3H-benzofuran-5-yl)-1-[2- (hydroxymethyl)-4- pyridyl]pyrazole-3-carboxamide | US10899774, Example 59
Type:
Small organic molecule
Emp. Form.:
C24H27N5O4
Mol. Mass.:
449.5023
SMILES:
CC1(C)Cc2cc(NC(=O)c3ccn(n3)-c3ccnc(CO)c3)c(cc2O1)N1CCOCC1
Structure:
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