Reaction Details Report a problem with these data
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Ligand
BDBM474210
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
34.0±n/a nM
Citation
 Kehler, J; Rasmussen, LK; Langgård, M; Jessing, M; Vital, PJ; Juhl, K Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors US Patent  US10905688 Publication Date 2/2/2021 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms:
61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1
Type:
Protein
Mol. Mass.:
61245.69
Organism:
Homo sapiens (Human)
Description:
P54750
Residue:
535
Sequence:
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
  
Inhibitor
Name:
BDBM474210
Synonyms:
7-(4-methoxybenzyl)-6-methyl-3- (1-(4-methylthiazol-2- yl)ethyl)imidazo[1,5-a]pyrazin- 8(7H)-one | US10858362, Example 90 | US10912773, Example 90 | US11472810, Example 90
Type:
Small organic molecule
Emp. Form.:
C21H22N4O2S
Mol. Mass.:
394.49
SMILES:
COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)c2nc(C)cs2)cc1
Structure:
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