Reaction Details Report a problem with these data
Target
Amyloid-beta precursor protein [1-42]
Ligand
BDBM50185987
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
Ki
4.60±3 nM
Citation
 Routier, S; Suzenet, F; Chalon, S; Buron, F; Vercouillie, J; Melki, R; Boiaryna, L; Guilloteau, D; Pieri, L Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases US Patent  US10906900 Publication Date 2/2/2021 
Target
Name:
Amyloid-beta precursor protein [1-42]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
3256.81
Organism:
Homo sapiens (Human)
Description:
aa 1-42
Residue:
32
Sequence:
MLPGLALLLLAAWTARALEVPTDGNAGLLAEP
  
Inhibitor
Name:
BDBM50185987
Synonyms:
2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2-yl)ethylidene)malononitrile | CHEMBL207649 | US10906900, FDDNP | US9452985, FDDNP (reference for comparison)
Type:
Small organic molecule
Emp. Form.:
C18H16FN3
Mol. Mass.:
293.3381
SMILES:
[#6]-[#7](-[#6]-[#6]F)-c1ccc2cc(ccc2c1)-[#6](\[#6])=[#6](\C#N)C#N
Structure:
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