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Target
Beta-3 adrenergic receptor
Ligand
BDBM484051
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
IC50
17470±n/a nM
Citation
 Tran, T; Do, Q; Ullman, B; Blackburn, AC; Nagura, M Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto US Patent  US10927123 Publication Date 2/23/2021 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM484051
Synonyms:
(S)-1-((R)-8-(4'- (aminomethyl)-4- fluorobiphenyl-3- ylsulfonyl)-1-oxa-8- azaspiro[4.5]decan-3- ylamino)-3-(3-(1- (hydroxymethyl) cyclopropylsulfonyl) phenoxy)propan-2-ol | US10927123, Compound 169
Type:
Small organic molecule
Emp. Form.:
C34H42FN3O8S2
Mol. Mass.:
703.841
SMILES:
NCc1ccc(cc1)-c1ccc(F)c(c1)S(=O)(=O)N1CCC2(C[C@H](CO2)NC[C@H](O)COc2cccc(c2)S(=O)(=O)C2(CO)CC2)CC1 |r|
Structure:
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