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Target
Beta-3 adrenergic receptor
Ligand
BDBM484065
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
IC50
27830±n/a nM
Citation
 Tran, T; Do, Q; Ullman, B; Blackburn, AC; Nagura, M Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto US Patent  US10927123 Publication Date 2/23/2021 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM484065
Synonyms:
(S)-l-(3-(l- (hydroxymethyl) cyclopropylsulfonyl) phcnoxy)-3-((S)-8-(4'- ((propylamino)methyl) biphenyl-3-ylsulfonyl)- 1-oxa-8- azaspiro[4.5]decan-3- ylamino)propan-2-ol | US10927123, Compound 244
Type:
Small organic molecule
Emp. Form.:
C37H49N3O8S2
Mol. Mass.:
727.93
SMILES:
CCCNCc1ccc(cc1)-c1cccc(c1)S(=O)(=O)N1CCC2(C[C@@H](CO2)NC[C@H](O)COc2cccc(c2)S(=O)(=O)C2(CO)CC2)CC1 |r|
Structure:
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