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Target
Beta-3 adrenergic receptor
Ligand
BDBM484075
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
IC50
21770±n/a nM
Citation
 Tran, T; Do, Q; Ullman, B; Blackburn, AC; Nagura, M Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto US Patent  US10927123 Publication Date 2/23/2021 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM484075
Synonyms:
1-ethyl-8-fluoro-3-((R)- 3-((S)-2-hydroxy-3-(3- (methylsulfonyl)phenoxy) propylamino)-1-oxa- 8-azaspiro[4.5]decan-8- ylsulfonyl)quinolin- 4(1H)-one | US10927123, Compound 322
Type:
Small organic molecule
Emp. Form.:
C29H36FN3O8S2
Mol. Mass.:
637.74
SMILES:
CCn1cc(c(=O)c2cccc(F)c12)S(=O)(=O)N1CCC2(C[C@H](CO2)NC[C@H](O)COc2cccc(c2)S(C)(=O)=O)CC1 |r|
Structure:
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