Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM484078
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence Assay
IC50
29490±n/a nM
Citation
 Tran, T; Do, Q; Ullman, B; Blackburn, AC; Nagura, M Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto US Patent  US10927123 Publication Date 2/23/2021 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM484078
Synonyms:
3-((R)-3-((S)-3-(3- (cyclopropylsulfonyl) phenoxy)-2- hydroxypropylamino)-1- oxa-8-azaspiro[4.5]decan- 8-ylsulfonyl)- 7-fluoroquinolin-4-ol | US10927123, Compound 329
Type:
Small organic molecule
Emp. Form.:
C29H34FN3O8S2
Mol. Mass.:
635.724
SMILES:
O[C@@H](CN[C@H]1COC2(C1)CCN(CC2)S(=O)(=O)c1cnc2cc(F)ccc2c1O)COc1cccc(c1)S(=O)(=O)C1CC1 |r|
Structure:
Search PDB for entries with ligand similarity: