Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM309529
Substrate
n/a
Meas. Tech.
Assay for IDO1 Enzymatic Activity Determination
IC50
590±n/a nM
Citation
 Kraus, M; Cauwenberghs, S; Crosignani, S; Driessens, G Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body US Patent  US10945994 Publication Date 3/16/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
46214.94
Organism:
Dog
Description:
A0A8C0MXE9
Residue:
407
Sequence:
MEDDGILLMESPQRIFEKYHIDEEMGFALPNPLEKLPPPYDEWISIAKNLPELIKKNELRKKVDELKILSIDGLSGHKLQRLARLALGYITMAYVWNQGDGDVRKVLPQNIAIPYCELSEKLGLPPILVYADCVLANWKKKDPNGPMTYENMDILFWFPGGDCSKGFFLVSLLVELAAASAIKVIPNLLKAVKNQDEVTLKKALHYIASCLHRAHKEFEEVHKHVDPSTFFKVLRIYLSGWKGNSKLPEGLKYEGFWENPKEFAGGSAAQSSIFQCFDILLGIQQCSGEEFAAEFLQEMRNYMPPAHRDFLLLLKSGPSVREFVRSRDDVELKADYNECVKAMVSLRKYHLKIVAKYIVIPASQQPKNNQASEESSEQKNKGTGGTNAMDFLKSVRTTTEKFLLIDH
  
Inhibitor
Name:
BDBM309529
Synonyms:
3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione | US10945994, Compound 1 | US9603836, Compound 1 | US9603836, Compound 1a | US9949951, 1a
Type:
Small organic molecule
Emp. Form.:
C12H9FN2O2
Mol. Mass.:
232.2105
SMILES:
Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
Structure:
Search PDB for entries with ligand similarity: